Overall objectives:

1 - Understand the organism's biochemical and physiological mechanisms which act on exposure to toxins, poisons, and drugs.
2 - Analysis from a molecular and biochemical point of view the interaction mechanisms of toxic agents with biological systems and toxic manifestations resulting from this interaction.
3 - Know the working and emerging areas of Toxicology.

Syllabus:

1 - Introduction to the curricular unit
1.1 - Presentation of the program, evaluation, and recommended bibliography
2 - Concept and general principles of Toxicology
3 - Assessment of toxicological risk
4 - Dose-Response relationship
5 - Disposition of toxic agents
6 - Toxicokinetics. Absorption, Distribution, Metabolism and Elimination of toxic agents (ADME)
6.1 - Xenobiotics biotransformation. Phase I and Phase II reactions
6.2 - Induction and inhibition of xenobiotic metabolism
7 - Mechanisms of toxicity. Repair mechanisms: molecular, cellular and tissue
8 - Toxic effects or embryotoxic and teratogenenic effects. Mutagenesis. Carcinogenesis
9 - Biomarkers in Toxicology
9.1 - Biomarkers of exposure and/or effect
9.2 - Biomarkers in risk assessment
9.3 - Biomarkers of environmental contamination
10 - Applied areas in toxicology
10.1 - Environmental Toxicology
10.2 - Occupational and social Toxicology
10.3 - Food Toxicology
10.4 - Cronotoxicology
10.5 - Forensic Toxicology
10.6 - Nanotoxicology and emerging areas in toxicology

Literature/Sources:

Curtis, D.K., Watkins, J.B. , 2004 , Essentials of Toxicology , McGraw-Hill. New York
Dinis-Oliveira, R.J., Carvalho, F.D., Bastos, M.L. (Coordenação). , 2018 , Toxicologia Fundamental , Lidel - Edições Técnicas, Lda
Leikin, J.B. (editor) , 2006 , Handbook of Nuclear, Biological, and Chemical Agent Exposures , CRS Publisher
Leikin, J.B., Paloucek, F.P. (editor) , 2002 , Poisoning and Toxicology Handbook , Lexi-Comp
Timbrell. J.A. , 2002 , Introduction to Toxicology , Taylor & Francis, London
Consulta livre , Artigos científicos no domínio da toxicologia ,

Assesssment methods and criteria:

Classification Type: Quantitativa (0-20)

Evaluation Methodology:
The process of teaching/learning focuses on autonomous work supported in the individual survey. Classes are based on interpretive, dialogic and interrogative expository methods, using powerpoint, the board and video animations, culminating in the resolution of toxicokinetic exercises. The student is proposed to research and present a scientific article in any field of applied toxicology, explaining it based on the acquired knowledge. The final grade results from the grade of a written test (60%) and the work presented (40%). Minimum grade for each part is 9.5 values.