Overall objectives:

Enable students to:

- Recognize the pharmacology of antimicrobials, as well as the general principles of antibiotic therapy;

- Recognize the spectrum of bacteria that cause infections and infectious diseases;

- Understand the role that the microbiology laboratory has in the choice and correct use of antibiotics;

- Know the clinical reasoning for the choice of empirical and targeted antimicrobial therapy;

- Indicate the basis of etiotropic therapy for the most important infectious diseases of the different systems/organs;

- To describe the problem of multidrug resistance and the consequences of antibiotic therapy;

Syllabus:

1 - Introduction; 

2 - Errors and controversies in antibiotic therapy; 

3 - Microbiology - agents of infection; 

4 - The role of the microbiology laboratory; 

5 - Antibiotics - pharmacology; 

6 - Principle of antibiotic therapy; 

7- Intra-abdominal infections; 

8 - Surgical antibiotic prophylaxis; 

9 - Urinary infection; 

10 - Meningitis; 

11 - Bacteremia; 

12 - Endocarditis; 

13- Treatment of infections in pediatrics; 

14 - Respiratory infection; 

15 - Other infectious diseases (Leptospirosis, Q fever, syphilis); 

16 - Infection of the skin and soft tissues; 

17 - Gastroenteritis; 

18 - Sexually transmitted diseases; 

19 - Resistance and multi-resistance - ESKAPE (MRSA, ESBL, CBP); 

20 - Correct use of antibiotics in patients in the hospital; 

21 - Assessment.

Literature/Sources:

Access Medicine. Flashcards. Pharamcology. Anti-Bacterial Agents (http://medicalflashcards.mhmedical.com/index.html?siteId=iL6hvvagsptyS2MgRUGUvg%3d %3d&referenceId=Rd1SxC8zes3aEe05VWBcJA%3d%3d#/dashboard/cards)

Access Medicine. Review Questions. Katzung & Trevor?s Pharamcology: Examination & Board Review. Chemotherapeutic Drugs. (http://accessmedicine.mhmedical.com/qa.aspx?resourceID=1576)

Joseph Guglielmo Chapter e1: Anti-Infective Chemotherapeutic & Antibiotic Agents. In: Current Medical Diagnosis & Treatment 2018. Maxine A. Papadakis, Stephen J. McPhee, Michael W. Rabow (Eds.). Access Medicine. (http://accessmedicine.mhmedical.com/content.aspx?sectionid=167994536&bookid=2192&R esultclick=2)

Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 13e. Laurence L. Brunton, Randa Hilal-Dandan, Björn C. Knollmann (Eds). Section VII: Chemotherapy of Infectious Diseases. (http://accessmedicine.mhmedical.com/book.aspx?bookid=2189)

Infectious Diseases Society of America (IDSA) Practice guidelines

https://www.idsociety.org/PracticeGuidelines/

Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases

Free and open online course (MOOC):

World health organization.
Antimicrobial Stewardship: A competency-based approach https://openwho.org/courses/AMR-competency

Assesssment methods and criteria:

Continuous evaluation

Theoretical Assessment - Exam with 40 multiple-response questions

Final evaluation

0.2*Continuous Assessment Grade + 0.8*Exam Grade

Approval in any of the subject areas requires that the Continuous Assessment and Theoretical Assessment be equal to or greater than 9.5 points.